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Clinical Benefits & The Löwenstein Difference
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CL I N I CAL BENE F I TS WH I T EPAPER
Löwenstein Sleep Therapy Products
NEXT-GENERATION SOURCING
S A N T È • LÖW E N S T E I N S L E E P T H E R A PY D E V I C E S
Clinical Benefits
What does successful sleep therapy treatment look like? There is no set formula for the successful treatment of sleep disordered breathing (i.e. obstructive sleep apnoea). The treatment process is a complex matter & intensely individual, when it comes to PAP therapy, a practical test & trial process fine-tuned & tailored to an individual’s experience & needs by a trained professional is the consistent way to optimise the treatment outcome. When asked what defines successful sleep apnoea treatment, the usual metric clinicians & specialists refer to is AHI (Apnoea Hypopnea Index) per hour. A score of less than 5 AHI/hr is the typical theoretical definition of clinical effectiveness in PAP therapy. In reality, therapy outcome revolves around more than AHI/hr. The following chart offers insight into how Santé & Löwenstein view therapy success.
Information/Motivation
Noticeable recuperative effect is prerequisite for better compliance
Prerequisite for an effective SDB therapy
COMPLIANCE
Affected by comorbidities, PAP, sleep hygiene, lifestyle
THERAPY SUCCESS
Mask & mouth are sealed
LOW LEAKAGE
RESTORATIVE SLEEP
Minimum requirement: elimination of respiratory events
Prerequisite for pressure build-up & event recognition
AHI
PAP effectiveness: mode, titration
3
The Löwenstein Difference The Löwenstein devices consistently demonstrate clinical efficacy (AHI
» Efficiency of pressure - consistently low Pmax & Pmean. » Pressure relief SoftPAP - No compromise on clinical outcome. Features are explored in detail below & in subsequent appendices.
Prisma RECOVER The Löwenstein white paper edition “Sleep Quality in CPAP/APAP Therapy”* challenges the traditional perception of AHI as the only metric in APAP/CPAP Therapy. The paper outlines the importance of restorative or deep sleep (slow-wave-sleep) which shows a greater correlation to an improvement in daytime sleepiness compared to AHI. The innovative Prisma RECOVER algorithm (inbuilt within Prisma devices) analyses respiratory minute volume to provide an estimation of deep sleep. Deep sleep could be considered an important new metric of sleep quality in PAP therapy.
to treating sleep disordered breathing efficiently. The prisma devices have a forced oscillation amplitude of approx. 0.4 hpa (or cmH20) which is superimposed by the device blower.* The minor amplitude would suggest little chance of disruption to the patient’s sleep, with a precise event recognition achieved. “Study Hunter: Benchtest of AHI agreement in APAP (20A)”** was carried out with 4 devices: AirSense 10 (Resmed), Dreamstation Auto (Philips), S. Box (Sefam), Prisma20A (Löwenstein). It was concluded that Prisma20A together with Dreamstation Auto showed the highest accuracy level at 96% with PG as reference.
*Refer to Appendix 2 pages 1-8 **Refer to Appendix 3 Proactive Algorithm
*Refer to Appendix 1
Accuracy of AHI via FOT Modern algorithms frequently use forced oscillation technique (FOT) to reliably distinguish between obstructive & central sleep events, which is a prerequisite
Löwenstein devices measure each breath of the patient & airway obstruction occurring, this can then be observed in detailed graphs: respiratory flow graph & respiratory
next generation sourcing
S A N T È • LÖW E N S T E I N S L E E P T H E R A PY D E V I C E S
minute volume, & obstruction graph upon download & review of the detailed signal >Page 1 Page 2 Page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 Page 10 Page 11 Page 12 Page 13 Page 14 Page 15 Page 16 Page 17 Page 18 Page 19 Page 20 Page 21 Page 22 Page 23 Page 24 Page 25 Page 26 Page 27 Page 28 Page 29 Page 30 Page 31 Page 32 Page 33 Page 34 Page 35 Page 36 Page 37 Page 38 Page 39 Page 40 Page 41 Page 42 Page 43 Page 44 Page 45 Page 46 Page 47 Page 48 Page 49 Page 50 Page 51 Page 52 Page 53 Page 54
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